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A potential drop to the rest value is accompanied by a temporary influx of sodium ions from the intercellular liquid into the axon. If the nerve is excited by a 'subthreshold' current impulse, then a change in the membrane potential is produced that disappears at a small distance from the excitation site (at most 2 mm). A spike produced by a threshold or larger current impulse produces further excitation along the membrane, yielding further spikes that are propagated along the axon. As already pointed out, sodium ions are transferred from the intercellular liquid into the axon during the spike. This gradual formation and disappearance of positive charges corresponds to the flow of positive electric current along the axon. An adequate conductance of thick bare cephalopod axons allows the flow of sufficiently strong currents. In myelinized axons of vertebrates a much larger charge is formed (due to the much higher density of sodium channels in the nodes of Ranvier) which moves at high speed through much thinner axons than those of cephalopods. The myelin sheath then insulates the nerve fibre, impeding in this way the induction of an opposite current in the intercellular liquid which would hinder current flow inside the axon. The electrophysiological method described above is, in fact, a galvanostatic method (page 300). A more effective method (the so-called voltageclamp method) is based on polarizing the membrane by using a fourelectrode potentiostatic arrangement (page 295). In this way, Cole, Hodgkin and Huxley showed that individual currents linked to selective ion transfer across the membrane are responsible for impulse generation and propagation. A typical current-time curve is shown in Fig. 6.20. Obviously, the membrane ion transfer is activated at the start, but after some time it becomes gradually inhibited. The ion transfer rate typically depends on both

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Technology changes over the last 30 years have come in many shapes and sizes. Some have dramatically altered the face of computing, while others were a flash in the pan. This book focuses on two technologies (one mostly hardware and one mostly software) that are rapidly becoming key building blocks for the next generation of data centers. Blade servers and virtualization, working together, provide the flexibility, high availability, and manageability to enable utility computing, where computing resources are provisioned as needed to deliver services on demand to users anywhere, anytime. Blade server systems offer a highly modular, prewired, ultrahigh-density form factor for servers in the data center. With a design that allows shared redundant components such as power and cooling, network switches, and management modules, blade servers help reduce the number of components in the data center, as well as significantly increase the computing power per footprint. Virtualization also offers both space savings and a reduction in the number of physical components by allowing multiple servers to be consolidated as virtual servers onto a single physical server. Virtualization eliminates the problem of large numbers of highly underutilized servers, and the space, management, power, and cooling that they require. Both of these technologies are available in many forms from a variety of vendors, including major systems and software vendors as well as a number of innovative start-ups. Both have been successfully implemented in user environments ranging from small-medium businesses (SMB) to some of the largest enterprise data centers in the world. This book provides an overview of the benefits of these technologies, an architectural view of each, an analysis of the major offerings, user case studies, and considerations and tips for selecting and implementing products. We

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In the surface-grafted LC polymer lm, thermophysical properties are similar to those of a spincast lm. The in-plane orientation of Az groups in the surfacegrafted polymer lm may lead to different photoresponsive nature in the lm. Since the photoresponsive mesogens are oriented parallel to the substrate plane, the lm may be more sensitive to the polarization of LPL. In fact, LPL induces stronger in-plane anisotropy in the surface-grafted lm than in the ordinary cast lm. It is anticipated that this newly designed light-responsive surface may nd many new opportunities and applications.

hope you enjoy the book and that it makes your journey into implementing these technologies a smoother ride.

Fig. 6.20 Time dependence of the membrane current. Since the potassium channel is blocked the current corresponds to sodium transport. The upper line represents the time course of the imposed potential difference. (According to W. Ulbricht)

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Surface relief gratings (SRGs) (regular topological surface modi cation) formed via irradiation with an interference pattern of coherent argon ion laser beam (Fig. 8.8) were found about a decade ago (Kim et al., 1995; Rochon et al., 1995) and is perhaps the most interesting target in the current research of Az polymers. A great deal of data has been accumulated rapidly because of its basic phenomenological interest and its technological applications (Yager and Barrett, 2001;

458 the outer (bathing) and inner solution (the inside of a cephalopod membrane as much as 1 mm thick can be rinsed with an electrolyte solution without affecting its activity). The assumption that the membrane currents are due to ion transfer through ion-specific channels was shown correct by means of experiments where the channels responsible for transfer of a certain ionic species were blocked by specific agents. Thus, the sodium transfer is inhibited by the toxin, tetrodotoxin:

Viswanathan et al., 1999). Some chapters in this book deal with this fascinating research topic. Features of this phenomenon can be summarized as follows: (i) The lm material transfer occurs over micrometer distances, far beyond the dimension of single polymer chain, are achieved, and (ii) the inscribed relief can be erased by heating above a softening temperature or uniform irradiation of circularly polarized light (CPL). Most of the polymers employed for these studies possess a push pull type Az unit such as Disperse Red 1, and the physical state is amorphous in nature with no particular regular structure in the lm (Fig. 8.9). Other characteristics are further listed in Table 8.1. Most investigations have

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