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(0.5 x 0.4 nm in size) controlling the entrance of ions with a definite radius. The rate of transport of sodium ions through the channel is considerable: when polarizing the membrane with a potential difference 4- 60 mV a current of approximately 1.5 pA flows through the channel which corresponds to 6 x 106 Na+ ions per second practically the same value as with the gramicidin A channel. The sodium channel is only selective but not specific for sodium transport. It shows approximately the same permeability to lithium ions, whereas it is roughly ten times lower than for potassium. The density of sodium channels varies among different animals, being only 30 fim~2 in the case of some marine animals and 330 jurn"2 in the squid axon, reaching 1.2 x 104 fj,m~2 in the mammalian nodes of Ranvier (see Fig. 6.17). The potassium channel mentioned above (there are many kinds) is more specific for K+ than the sodium channel for Na+ being almost impermeable to Na + .

s- : p100 (nm) 0

Space savings and efficiency, packing more computing power into a smaller area Consolidation of servers to improve and centralize management as well as to improve utilization of computer assets Simplification and reduction in complexity (modularity, ease of integration, prewired configurations, shared components), ease of deployment, and improved manageability and serviceability ROI and improved TCO (increased hardware utilization, reduced OpEx)

Fig. 6.23 Single-channel currents flowing across the membrane between the protoplast and vacuole of Chara corallina. Among several channels with different conductivity the recordings of the 130 pS channel are recorded here. The zero line is at the top of each curve. (By courtesy of F. Homble)

0 20 20 20

461 The stochastic nature of membrane phenomena originating in channel opening and closing is not restricted to excitable cells Figure 623 shows the time dependence of currents flowing through a patch of the membrane between the tonoplast (protoplasma) and the vacuole in the isolated part of a cell of the freshwater alga, Chara corallina In this membrane there are three types of potassium channels with different conductivity and the behaviour of the 130 pS channel is displayed in the figure D E Goldman, A L Hodgkin, A P Huxley and B Katz (A L H and A P H, Nobel Prize for Physiology and Medicine, 1963, BK.

Packing more computing power into a smaller space was one of the main initial reasons for deploying blades. This reason is still significant for many data centers that are out of room. In an IDC survey of enterprise data centers in Europe in 2005, users ranked floor space as their number-two issue, surrounded by powerrelated issues as the number-one and number-three choices (see Figure 3.6). As IT organizations have responded to ever-increasing demands for additional processing power and storage capacity, many data centers have grown their IT hardware to the point of maxing out their floor space as well as their power and cooling capacity. In many cases, blade systems offer help in this area by providing a way to replace larger rack servers with the same or greater capacity in a smaller footprint. In fact, as blade vendors have implemented faster processors, two-way processors, and dual-core processors (with quadcore processors in 2007), the computing power per square foot has increased significantly over early blade systems. For instance, 60 blade servers might now fit in the same physical space as 42 rack-mounted servers (these numbers vary from vendor to vendor). In some cases, users have been able to buy back space in the data center by converting rack servers to blade servers. This may allow IT to postpone or even eliminate the cost of building a new data center that would otherwise have been required. In addition, significant space savings may be accomplished through consolidation via virtualization.

0 20 20

, 1970) developed a theory of the resting potential of axon membranes, based on the assumption that the strength of the electric field in a thin membrane is constant and that ion transport in the membrane can be described by the Nernst-Planck equations It would appear that this approach does not correspond to reality it has been pointed out that ions are transported through the membrane in channels that are specific for a certain kind of ion Thus, diffusion is not involved, but rather a jumping of the ions through the membrane, that must overcome a certain energy barrier In deriving a relationship for the resting potential of the axon membrane it will be assumed that, in the vicinity of the resting potential, the frequency of opening of a definite kind of ion channel is not markedly dependent on the membrane potential.

Figure 8.10. SRG formation by double-beam interference of coherent argon ion laser in different polarization modes.

The transport of ions through the membrane can be described by the same equations as the rate of an electrode reaction in Section 522 It will be assumed that the resting potential is determined by the transport of potassium, sodium and chloride ions alone The constants fcp are functions of the frequency of opening and closing of the gates of the ion-selective channels The solution to this problem will be based on analogous assumptions to those employed for the mixed potential (see Section 584) The material fluxes of the individual ions are given by the equations.

3